
Triglycidyl isocyanurate
CAS No. 2451-62-9
Triglycidyl isocyanurate( Tris(2,3-epoxypropyl) Isocyanurate | TGI | TGIC | Teroxirone )
Catalog No. M27583 CAS No. 2451-62-9
Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 36 | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameTriglycidyl isocyanurate
-
NoteResearch use only, not for human use.
-
Brief DescriptionTriglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.
-
DescriptionTriglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.(In Vitro):Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.(In Vivo):Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice.
-
In VitroTriglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres. Cell Viability Assay Cell Line:A549, H460 and H1299 cells Concentration:0 μM; 5 μM; 10 μM; 30 μM Incubation Time:48 hours Result:Inhibited tumor cells growth in soft agar.Western Blot AnalysisCell Line:A549, H460 and H1299 cells Concentration:0 μM; 5 μM; 10 μM; 30 μM Incubation Time:48 hours Result:Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
-
In VivoTriglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice. Animal Model:Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area Dosage:1.8mg/kg and 3.6 mg/kg Administration:Subcutaneous injection; every 2–3 days for total seven times; 30 days Result:Inhibited the growth of xenograft tumors.
-
SynonymsTris(2,3-epoxypropyl) Isocyanurate | TGI | TGIC | Teroxirone
-
PathwayApoptosis
-
TargetApoptosis
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2451-62-9
-
Formula Weight297.267
-
Molecular FormulaC12H15N3O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (168.20 mM)
-
SMILESO=c1n(CC2CO2)c(=O)n(CC2CO2)c(=O)n1CC1CO1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Guoju Chai, et al. Preparation method of indoline compound, indoline compound and application. CN110452149B
molnova catalog



related products
-
TD52
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter.
-
AGN 192870
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
-
Sandacanol
Sandacanol(Sandranol) is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.